Ceramic Hydroxyapatite requires special consideration during process scale chromatography packing. This is primarily due to the high specific gravity and rapid settling rate of CHT, moreover for the CHT 80µm that has a free-settling velocity of 125-275 cm/hr.  Additionally, as the CHT media is sensitive to mechanical shear, it can lead to fracturing of particles and creation of fines.

VERDOT InPlace columns offer a unique solution for media such as CHT with smooth slurry transfer, packing in axial compression and unpacking with minimal amount of buffer.

Please refer to the technical note CHT in VERDOT InPlace to know more about it. This technical note gives information on the best practices of using CHT in VERDOT InPlace columns.